The C6 was used for many years in both trucks and cars. If there is a difference in the bolt patterns then I would think it would have to be in the engine it mated to. Ford made a few I6 engines and the C6 mated to a few including the 250 and 300.
The C6 was a good transmission and was replaced by the E4OD which should bolt right up to your truck and gives a better gear range over the C6 since it is a 4 speed versus 3 in the C6.
The C6 was a good transmission and was replaced by the E4OD which should bolt right up to your truck and gives a better gear range over the C6 since it is a 4 speed versus 3 in the C6.